Bioavailability assessment of hydroxymethylglutaryl coenzyme A reductase inhibitor utilizing pulsatile drug delivery system: a pilot study
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چکیده
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a study on construction of iranian life tables: the case study of modified brass logit system
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15 صفحه اولHuman hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity.
While statins, hydroxymethylglutaryl-coenzyme A reductase (HMGCR) inhibitors, are clinically proven to reduce plasma cholesterol levels, a wide variation in inter-individual response to statin therapy has been observed. Pharmacogenetic studies have identified multiple loci that potentially contribute towards the statin response, including the HMGCR gene. To examine, if a statin-resistant, catal...
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Pulsatile drug delivery system (PDDS) is useful in the treatment of disease, in which drug availability is timed to match rhythms of disease, in order to optimize therapeutic effect and minimize side effects. PDDS have attracted attraction because of their multiple benefits over conventional dosage forms. The specific time that patients take their medication is very important as it has signific...
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Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. Identification of the inhibitors was...
متن کاملPurification and properties of a protein inhibitor that inhibits phosphatase 2A activity when hydroxymethylglutaryl coenzyme A reductase is the substrate.
A heat-stable protein inhibitor of the hydroxymethylglutaryl-CoA reductase phosphatase 2A activity has been identified and purified to homogeneity, as judged by polyacrylamide gel electrophoresis. The apparent molecular mass was 20,000 Da. The protein lost its inhibitory properties when incubated with trypsin or treated with ethanol. The inhibitor protein does not inhibit type 1 phosphatase whe...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2014
ISSN: 1071-7544,1521-0464
DOI: 10.3109/10717544.2014.947049